Idiopathic Pulmonary Fibrosis: High Resolution CT Findings Correlated with Pulmonary Function Tests
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- Category: Vol. 81, March 2013
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Idiopathic Pulmonary Fibrosis: High Resolution CT Findings Correlated with Pulmonary Function Tests,EMAN ABO-EL HAMD, WAFAA A. HASSAN and HAMADA KAWASHTY
Abstract
Objective: Retrospective study was done at Assuit and Al-Azhar Universities, Egypt to demonstrate and compare the high-resolution CT and the pulmonary function tests findings of the idiopathic pulmonary fibrosis.
Patients and Methods: This study was done during 2010- 2012 on files of IPF patients. It included: Age, sex, clinical presentation, HRCT findings, and pulmonary function tests. The HRCT scans and the PFT results were retrospectively analysed and compared for 43 patients having IPF.
Results: All patients (43) had a restrictive ventilatory impairment. HRCT showed predominantly reticular abnor-malities in five patients. In the remaining 38 cases, HRCT scan showed a mixed pattern (ground-glass and reticular abnormalities and honeycombing). A significant correlation was observed between the overall disease extent in the HRCT and both FVC (r=0.350, p=0.001*) and DLCO (r=0.296, p=0.004*). Significant correlations was also observed with the extent of reticulation and with honeycombing. 18 patients had concurrent emphysema with IPF. The mean diameter of the main pulmonary artery was 30.9mm.
Conclusion: HRCT provides several advantages in the examination of patients with IPF. HRCT is a useful non invasive procedure for confirming the presence of pulmonary hypertension in some patients with diffuse lung disease. Both FVC and DLCO are the pulmonary function studies that could reflect the severity of disease extent and thus disease progres-sion in IPF, as shown by HRCT. Thus, conventional pulmonary function tests have demonstrated value in the assessment of IPF patients.