Measurement of Serum Nitric Oxide in Different Types of Psoriasis
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- Category: Vol. 82, September 2014
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Measurement of Serum Nitric Oxide in Different Types of Psoriasis, SHERINE H. ABD EL-RAHMAN and ASMAA M. EL-REFAEI
Abstract
Background: Psoriasis is a chronic, inflammatory, and hyperproliferative disease. Recently there have been studies regarding increases in the levels of NO in inflammatory dermatoses including psoriasis.
Objective: The aim of this study was to measure serum nitric oxide (NO) levels in patients with active psoriasis, to correlate these levels with duration and severity of the disease and compare them with those in normal individuals.
Patients and Methods: In this study, 40 patients with psoriasis were scored with PASI score and the levels of serum nitric oxide were detected by Greiss method. The results were compared with forty (40) healthy volunteers. The relation of the results with the clinical severity, duration of the disease as well as duration of the current episode were also evaluated.
Results: Out of the 40 patients with psoriasis 30 (75%) presented with chronic plaque psoriasis, 7 (17.5%) presented with acute attack of guttate psoriasis, 1 (2.5%) patient with erythrodermic psoriasis, 1 (2.5%) with pustular psoriasis and 1 (2.5%) with scalp psoriasis. The duration of the disease ranged between 6 months to 25 years while the PASI score ranged between (1.60- 49.50). The mean NO level in psoriatic group was 125.0μ mol/L with SD 38.77, while in the control group it was 42.37μ mol/L with SD 23.57. The difference was statistically significant (p<0.001). A positive correlation was observed between sNO levels and each of the following: Duration of the disease, PASI score, age of patients and age of disease onset.
Conclusion: The data of this study confirmed the vital role played by NO in the pathogenesis of psoriasis. The NO concentration in the blood serum considerably increased in patients with severe symptoms of disease. Measuring of serum NO may permit an objective estimation of the intensity of inflammatory response, as well as an opportunity to propose the prognosis of psoriasis.