Metabolic Syndrome Among Infertile Women with Polycystic Ovary Syndrome
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- Category: Vol. 82, September 2014
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Metabolic Syndrome Among Infertile Women with Polycystic Ovary Syndrome, HANY AYASH and AMRO ABO EL-EZZ
Abstract
Objectives: This study was designed to detect the preva-lence of metabolic syndrome (MS) among infertile women with polycystic ovary syndrome (PCOS).
Study Design: Prospective cross sectional study.
Patients and Methods: Two hundred and twenty (220) infertile PCOS women were included in this study to detect the prevalence of MS among infertile PCOS women. Diagnosis of PCOS was based on at least two of ESHRE/ASRM criteria and diagnosis of MS was based on at least three of NCEP ATP III criteria. A standard questionnaire was used to document length of menstrual cycles, personal, medical and family history of diabetes, hypertension, obesity and ischemic heart disease. Signs of androgen excess and insulin resistance were noted in the physical examination. Anthropometric measure-ments were done to measure waist circumference and hip circumference. Height was recorded in centimeters and weight in kilograms. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters (kg/m2). Overnight fasting blood sample and a 75 gram oral glucose tolerance test was obtained in all studied women. Impaired fasting glucose, impaired glucose tolerance test and diabetes were defined in accordance with the American Diabetes Association revised definition. Thyroid stimulating hormone (TSH), prolactin, total testosterone, sex hormone-binding globulin (SHBG), and a fasting lipid profile levels were also evaluated in all studied women. Trans-vaginal ultrasound was done to measure; ovarian volume and number of follicles in both ovaries.
Results: The prevalence of MS in studied PCOS women was 30.5% (67/220). Three features of MS were present in 44 cases (20%), four features in 18 cases (8.2%) and all five features were present in 5 cases (2.3%) of the studied PCOS women. There is strong positive correlation between prevalence of MS and both age and BMI of the studied women, the prevalence of MS increased with increased age and BMI of the studied PCOS women. Logistic regression analysis showed that; the age >25 and waist-hip ratio >!0.85 were powerful predictors for the prevalence of MS in PCOS women.
Conclusion: The prevalence of metabolic syndrome was 30.5% in the studied PCOS women. The age above 25 years and waist-hip ratio >!0.85 were powerful predictors for prev-alence of MS in PCOS women than other parameters.