Magnesium Sulphate Versus Labetalol for Cardioprotection in Severe Preeclamptic Parturients Undergoing Cesarean Section Under Epidural Anesthesia
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- Category: Vol. 83, March 2015
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Magnesium Sulphate Versus Labetalol for Cardioprotection in Severe Preeclamptic Parturients Undergoing Cesarean Section Under Epidural Anesthesia, AFAF A. ABDALLAH, NEVAN M. ELMEKAWY, WAEL M. SAMY, WAEL S. ELSHERBINEY, REHAM A. MOHSEN and YASMIN S. IBRAHIM
Abstract
Introduction: Preeclampsia is a state of generalized vas-oconstriction and hypoperfusion. It is also a risk factor of myocardial injury. Magnesium sulphate is the drug of choice for seizure prophylaxis and also it has cardioprotective effect. Labetalol can be used for control blood pressure as well as to seizure prophylaxis.
Objective: To Compare between the effects of magnesium sulphate and labetalol as cardioprotective agents in severe preeclamptic patients.
Patients and Methods: 60 patients with severe preeclamp-sia were enrolled in the study. They were randomly allocated into two groups. The first group received magnesium sulphate while the other group received Labetalol. Serial Troponin I (cTn I) measurements were obtained.
Results: Serum cTnI didn’t show any statistically signif-icant differences between the two groups at different sampling times (p>0.05). Also, the results of this study showed that serial post-operative cTnI level did not show any significant rise if compared to the baseline in both groups.
Conclusion: Labetalol can be used as magnesium for cardioprotection in patients with severe preeclampsia as they have comparable troponin levels with magnesium sulphate during the first 24 hours following delivery by cesarean section.