Estimation of Matrix Metalloproteinase-9 and Interleukin-17 Tissue Levels in Stable, Non- Segmental Vitiligo
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- Category: Vol. 84, September 2016
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Estimation of Matrix Metalloproteinase-9 and Interleukin-17 Tissue Levels in Stable, Non- Segmental Vitiligo, NAHLA S. HUNTER, HEBA M. MASHALY, DINA A. DORGHAM, OLFAT G. SHAKER and SARAH I. ISMAIL
Abstract
Background: Patients with vitiligo have disturbed melanосуtiс milieu either by rise or decline in levels of certain mediators.
Objectives: The study aimed at measuring Matrix Metalloproteіnase-9 (ММР-9) and Interlcukіn-17 (IL-17) tissue levels in patients with stable, Non-Segmental Vialigo (NSV) and determining if there is any relation between their levels and patients' age and sex, and disease activity, extent and duration.
Patients and Methods: Thirty patients with stable NSV were recruited. Punch skin biopsies were taken and examined by ELISA to detect the levels оf ММР-9 and IL-17.
Results: All cases with stable NSV had low ММР-9 and elevated IL-17 levels. None of them was related to the age, sex, disease activity and duration, and extent of vitiligo.
Conclusion: Imbalance in ММР-9 and IL-17 levels is directly related to vitiligo pathogenesis and targeting these mediators could be a promising line of treatment.