Evaluation of Fundus Autofluorescence as a Prognostic Factor in Diabetic Macular Edema
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- Category: Vol. 84, September 2016
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Evaluation of Fundus Autofluorescence as a Prognostic Factor in Diabetic Macular Edema, LAMEECE MOUSTAFA, SHERIF SHETA, RANDA ABD EL-RAZEK, GEHAN HELMY and DINA ELFAYOUMI
Abstract
Purpose: То determine if the changes in fundus autofluorescence patterns in cases of diabetic macular edema following intravitreal injections of bevacizumab correlate with visual acuity and serve as prognostic factors.
Design: Randomized, prospective interventional study.
Methods: Forty eyes with non-ischemic cystoid or diffuse edema underwent SW-FAF imaging with a cSLO prior to and after three intravitreal injections of bevacizumab and the pattern of hyperautofluorescence was determined (number and total area of hyperautofluorescent spots). SD ОСТ was done to determine the CFT, integrity of the IS/OS junction and detect other visually significant findings. The changes in BCVA were observed at baseline and post injection.
Results: 35 cases (87.5%) had abnormal fovea! hyperautofluorescence. Pre injection, the mean BCVA was best for those with no then mu!tiple then single spots and post injection, the BCVA was best for those with multiple spots then no spots then single spots, but the differences were non significant. On subdivision of cases into groups according to the change in their BCVA, in 23 cases the visual acuity improved, 15 remained the same and 2 cases deteriorated. The improved visual acuity group had lower CPT, less hyperautofluorescent spots and a slightly greater total area of hyperautofluorescence but the differences were not significant.
Conclusion: There are certain PAP patterns in DME, but they cannot be definitively correlated with visual prognosis following therapy.