The Role of a Single Serum Progesterone Measurement in Relation to Early Pregnancy Failure and Fetal Viability
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- Category: Vol. 84, September 2016
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The Role of a Single Serum Progesterone Measurement in Relation to Early Pregnancy Failure and Fetal Viability, AHMED M. ELEWA, AHMED E.A. MANSOUR, AMR A. SHARAF EL-DEEN and ASMAA A. BIOUMI
Abstract
Background: Early pregnancy failure is a common pregnancy complication. In clinical practice, the time delay to distinguish viable from non-viable pregnancy is often distressing to patients and physicians.
Aim of the Work: The study aims to evaluate the value of a single estimation of maternal serum progesterone level at the time of vaginal bleeding and or uterine cramping in relation to early pregnancy failure and fetal viability.
Methods: Thе study was carried out in the Obstetric and Gynecology Department of Benin General and Benin University Hospitals during a period from November 2014 to December 2015. 151 pregnant women were recruited and are classified into a control group (50 pregnant women) coming for routine antenatal care and continue their pregnancy to 20 weeks of gestation, and study group (101 pregnant women), all complaining of vaginal bleeding and or abdominal pain. The study were flirtherly classified according to their pregnancy outcome into; (A) Failed early pregnancy group formed of 44 pregnant women (complete, incomplete, blighted ovum, missed miscarriage), (B) Threatened continued group formed of 40 pregnant women and their pregnancies continued to at least 20 weeks, (C) Threatened non-continued group formed of 17 pregnant women and their pregnancies ended by miscarriage. Single measurement of serum progesterone was carried out. The outcome of pregnancy was followed until at least 20 weeks of gestation to ascertain viability of the fetus
Results: Median serum progesterone level was significantly low in failed early pregnancy group (cut off level 10.Зпg/m1). The level was significantly lower in threatened non continued group than that of threatened continued and control groups At a cut off value of 15.5ng/ml, progesterone had 70.6% sensitivity 87.5% specificity, PPV of 70.6%, NPV of 87.5% and accuracy of 823%. Conclusion: These findings indicate that serum progesterone could be used as a marker for early pregnancy failure.