The Relationship between the Serum Level of Vitamin D and Bronchial Asthma,
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The Relationship between the Serum Level of Vitamin D and Bronchial Asthma, AMR M. HELMY
Abstract
Background: Asthma represents one of the most common chronic diseases and is a major public health problem worldwide. Asthma is characterized by lower respiratory tract inflammation associated with bronchial hyper responsiveness with variable and reversible airflow obstruction. Vitamin D insufficiency is increasingly recognized in the general population and has been largely attributed to dietary, lifestyle and behavioral changes. Vitamin D has several effects on the innate and adaptive immune systems that might be relevant in the primary prevention of asthma, in the protection against or reduction of asthma morbidity and in the modulation of the severity of asthma exacerbations.
Aim: To study the relationship between the serum level of vitamin D and bronchial asthma.
Methods: 60 patients with bronchial asthma and 30 healthy controls were recruited in this study. They were divided into two groups; Group (I): Included 60 patients with bronchial asthma, they were subdivided into 2 subgroups: Subgroup (Ia): Included 30 patients with asthma during exacerbation and Subgroup (Ib): Included 30 patients with controlled asthma (asthma in between attacks). Group II: Included 30 healthy controls. AU were subjected to complete clinical examination, laboratory investigations including measurement of sex-urn level of 25 hydoxy (ОН) vitamin I), ventilatory function tests and radiological investigations including chest X-ray.
Results: Patients with bronchial asthma had lower serum levels of 25 (ОН) D (1316.5ng/m1) compared to control group (34t9ng/m1) with more significant decreased levels among patients with asthma exacerbation than patients with controlled asthma (9.8713.5 and 16.816.7 respectively). Both asthma subgroups have 25 (ОН) D insufficiency (530ng/mL). FEV1 showed positive correlation with serum 25 (ОН) D level. Conclusion: Vitamin D insufficiency is prevalent in asthmatic patients and is strongly associated with asthma exacerbation. Measurement of serum 25 (ОН) D is advised in asthmatic patients especially those with recurrent exacerbations as vitamin D supplementation might affect the clinical outcome.