Histological and Histomorphometric Reorganization of the Adrenal Cortex of Adolescent Male Albino Rat Following Exposure to Stress
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- Category: Vol. 84, September 2016
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Histological and Histomorphometric Reorganization of the Adrenal Cortex of Adolescent Male Albino Rat Following Exposure to Stress, FAYZA A. ABD EL-GAWAD, SHERIF M. ZAKI, EHAB A. EL-SHAARAWY, RASHA A. RADWAN and BASMA E. ABOUL-HODA
Abstract
Background: Stress results in histological as well as morphometric changes in the adrenal cortex. This study is to demonstrate these changes during adolescent stage of development in the male albino rat.
Material and Methods: Eighty male adolescent albino rats (4-6 months old) of Wistar strain were included; they were divided into two groups; the control group and the stressed group. The stressed group was subjected to restraint stress for 14 days. The glands were subjected to light microscopic examination using Их & E and electron microscopic examination using transmission electron microscope. Quantitative histomorphometric estimations included morphometric measurement for thickness of the three adrenocortical zones.
Results: Imposing stress resulted in changes in the histological features of the adrenal cortex as well as changes in the size of the different adrenocortical zones, the most remarkable of which was increase in the thickness of the ZF and ZR and decrease in the thickness of the ZG. This difference was found to be statistically significant. Ultrastructural changes included the appearance of indented nuclei and occasional shrunken ones as well as dense lipid droplets.
Conclusion: That adrenal cortex becomes modified in its cytological characteristics and proliferative features in response to stress. This further highlights the relevance of exploring and understanding the contribution of these adrenoconical changes to many of stress-related diseases