Carpal Tunnel Syndrome in Egyptian Hypothyroid Patients: Prevalence and Relation with Clinical, Laboratory and Electrophysiological Findings
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- Category: Vol. 84, December 2016
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Carpal Tunnel Syndrome in Egyptian Hypothyroid Patients: Prevalence and Relation with Clinical, Laboratory and Electrophysiological Findings, NAHLA A. SALAMA, MAHMOUD M. ASHOUR, HANAN SALAH, AHMAD M. HASSANEEN and AZZA A.Y. MEGAHED
Abstract
Background: Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve entrapment syndrome. Hypothy-roidism is included as an important risk factor for CTS. However, this association is still unclear.
Objective: Assessing the prevalence of CT in patients with hypothyroidism and evaluation of the relation between occurrence of CTS in these patients with clinical, laboratory and electrophysiological findings.
Patients and Methods: The study included 200 females divided into 2 groups: 120 patients with primary hypothyroid-ism, and 80 healthy age-matched controls. All subjects were subjected to full history taking, thorough clinical examination (general and neurological), calculation of Body Mass Index (BMI), and electrodiagnosis for CTS. Laboratory investigations were performed for all patients including measurement of serum levels of Thyroid Stimulating Hormone (TSH), Free Thyroxine (FT4) , Free Tri-Iodothyroxine (FT3), anti-Thyroid Peroxidase antibodies (anti-TPO), and anti-Thyroglobulin antibodies (anti-TG).
Results: Hypothyroid patients had a significantly higher prevalence of CTS (35.8 %) as compared to the control group (8.8%). There was a significant relation between occurrence of CTS and patients' age and BMI. Patients' not taking adequate thyroxine replacement therapy had significantly higher fre-quency of CTS in comparison to those receiving this therapy. There was a significant difference in serum levels of TSH, FT4, FT3, anti-TPO and anti-TG between hypothyroid patients with CTS and those without CTS.
Conclusion: CTS can be considered a common manifes-tation associated with hypothyroidism.
Initial evaluation (clinical and electrophysiological) and regular checking for CTS in hypothyroid patients are recom-mended.