The Therapeutic Effect of Gamma-Aminobutyric Acid Analogue, Gabapentin, and Caffeine in the Nitroglycerin-Induced Migraine Rat Model (Gabapentin and Caffeine in Migraine)
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- Category: Vol. 84, December 2016
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The Therapeutic Effect of Gamma-Aminobutyric Acid Analogue, Gabapentin, and Caffeine in the Nitroglycerin-Induced Migraine Rat Model (Gabapentin and Caffeine in Migraine), REHAB E. ABO EL-GHEIT and LAMEES M. DAWOOD
Abstract
Introduction: Migraine is a complex neurovascular disor-der. Gabapentin is a structural analogue to Gamma-Amino Butyric Acid (GABA), with strong anticonvulsant and anal-gesic activities, while caffeine is an adjuvant in analgesic formulations.
Aim: The aim of this study was to evaluate the potential therapeutic effect of combined GABA analogue, gabapentin and caffeine in glyceryl trinitrate (NTG) migraine rat model and the possible underlying mechanisms.
Methods: Thirty male albino rats were received either (NTG, 10mg/kg, i.p.) or saline (NTG vehicle). NTG treated rats received combined gabapentin/caffeine or their vehicles. Normal rats were taken as control group. The analgesic activity was evaluated by Formalin Test (FT). Dural inflammation was assessed by Evans Blue Dye (EBD) extravasation. Serum total tryptase was measured as an indicator of Mast Cells (MCs) activation. Glutamic acid and GABA levels in Trigem-inal Nucleus Caudalis (TNC) tissue homogenate were assayed
Results: Gabapentin/caffeine treatment significantly alle-viated the nociception during both phases of the FT with greater reduction in the second phase possibly through MCs stabilization, anti-inflammatory effect with restored neurotrans-mitters balance.
Conclusion: These data suggest that GABA analogue, gabapentin together with caffeine may abort migraine attack and represent a potential therapeutic tool for the treatment of migraine.