Effects of w-3 Fatty Acids and Estrogen Replacement Therapy on Ovariectomy Induced Osteoporosis in Female Albino Rats
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- Category: Vol. 84, December 2016
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Effects of w-3 Fatty Acids and Estrogen Replacement Therapy on Ovariectomy Induced Osteoporosis in Female Albino Rats, NAHED S. MOHAMED, MOHAMED A. SALEH, AYMAN S. SOLIMAN and AHMED M. SIDDIQ
Abstract
Background: Fatty acids especially omega 3 unsaturated fatty acids has known anti-inflammatory effects. There are different mechanisms by which dietary fatty acids may affect bone, but their protective effect against postmenopausal osteoporosis remains a controversial issue.
Material and Methods: This study was applied on 50 female albino rats that were divided into 5 equal groups: Sham operated group, ovariectomy group, ovariectomy + flaxseed oil group (0.4g/kg/day), ovariectomy + fish oil administered group (0.4g/kg/day) and ovariectomy + estrogen replacement therapy group (30mg/kg 5 days a week). The study proceeded for 12 weeks then femurs Bone Mineral Density (BMD) were measured with Dual-energy X-ray Absorptiometer (DXA) scan and serum osteoprotogerin (OPG), bone specific alkaline phosphatase (B-ALP) and tumour necrosis factor alpha (TNF-a) were measured.
Results: There was a significant (p<0.01) increase in the BMD of the treated groups compared with the ovariectomy group. There were significant (p<0.001) differences in the means of serum bone markers measures of the treated groups versus the ovariectomy group in the form of significant increase in OPG and a significant (p<0.001) decrease in B-ALP and TNF-a of the treated groups compared with the ovariectomy group. This study showed a significant negative correlation between BMD and B-ALP (r=–0.375, p<0.001).
Conclusion: According to this study the chronic adminis-tration of omega 3 fatty acids (flaxseed oil-fish oil) has a preventive effect against osteoporosis and suppression of bone turn over process appears to have a role in this preventive effect.