Efficacy of Aerobic Exercises on Anthracycline-Induced Cardiotoxicity in Post Mastectomy Patients
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- Category: Vol. 84, December 2016
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Efficacy of Aerobic Exercises on Anthracycline-Induced Cardiotoxicity in Post Mastectomy Patients, ASMAA N. MAHMOUD, KHADRA M. ALI, SAMAH H. NAGIB and AHMED A. ALNAGAR
Abstract
Background: Anthracycline-containing chemotherapy (e.g., doxorubicin) is well known to cause dose-dependent, progressive cardiac damage clinically manifest as decreased left ventricular ejection fraction and, ultimately, heart failure.
Aim of the Work: To examine the effects of aerobic exer-cises during the course of Dox treatment on cardiac function.
Patient and Methods: The study included 30 female patients who received doxorubicin post mastectomy. They were divided randomly in two groups, group (A) exercise group and group (B) control group. Cardiac function is mea-sured by ECG and quality of life is measured by EQ-5D Scale.
Results: Cardiac function is preserved in group (A) who received aerobic exercise and quality of life is improved whereas cardiac function of group (B) is worsen and quality of life is affected.
Conclusion: The current study suggested that aerobic exercises maintains or improves cardiac function and quality of life and after cancer treatment. However, it is critical that exercise be individualized to specific needs of the cancer survivor to prevent exacerbation of cancer treatment toxicities.