Study of the Performance of Heart Type Fatty Acid Binding Protein (H-FABP) in Early Diagnosis of Acute Myocardial Infarction
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- Category: Vol. 84, December 2016
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Study of the Performance of Heart Type Fatty Acid Binding Protein (H-FABP) in Early Diagnosis of Acute Myocardial Infarction, MOHAMED MOMTAZ, DINA HISHAM and MOHAMED ABD EL-MONIEN EL-DERDIRY
Abstract
Background: The management of patients with chest pain can be considerably improved by implementation of serial cardiac markers identifying Acute Myocardial Infarction (AMI) in the very early stages. Heart-type Fatty Acid Binding Protein (H-FABP) is released into the circulation early (1 hour) after myocardial injury.
Aim of this Work: We aimed to investigate the role of H-FABP (Immunoturbidimetric Assay) as a cardiac marker in early diagnosis of AMI.
Methods: The current study was conducted on 82 patients with AMI, with mean age 54.8±10.5 years. The patients were divided into two groups according to the onset of chest pain: Group (1) with chest pain less than or equal four hours (mean 3.34±0.617 hours) minimum 1 hour and maximum 4 hours and group (2) chest pain more than four hours (mean 7.59±0.65 hours) minimum 5 hours and maximum 24 hours. All patients were examined clinically and by 12-lead ECG and levels of H-FABP, Troponin I, CK-MB and LDH were measured on presentation.
Results: H-FABP at a cut-off level of 3.4ng/ml had the sensitivity (79.4%) and specificity (82.6%) to diagnose AMI within 4 hours after onset of chest pain. The other examined markers had significantly lower sensitivity than H-FABP (Troponin I 61%), (CK-MB 65%), and (LDH 54%). While (Combined H-FABP and Troponin I sensitivity was 91.1%).
Conclusions: H-FABP assays (Immunoturbidimetric As-say) rapidly measure H-FABP in clinical practice for early diagnosis of AMI (mainly if combined with Troponin I), to improve the outcome of AMI patients.