The Effect of Hyperinsulinemia on Colonic Inflammation in A Model of High Carbohydrate Diet Induced Type II Diabetes Mellitus in Female Rats; Possible Underlying Mechanisms
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- Category: Vol. 84, December 2016
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The Effect of Hyperinsulinemia on Colonic Inflammation in A Model of High Carbohydrate Diet Induced Type II Diabetes Mellitus in Female Rats; Possible Underlying Mechanisms, MAGDA M. EL-HAMZAWY, OMNIA M. ABD EL-MAKSOOD, HEBA S. IBRAHIM, LAILA A. RASHED, RABAB A. RASHEED and NEMMAT M. ABD EL-GILIL
Abstract
Introduction: Insulin and its status are key components in metabolic syndrome. Data indicates a link that may connect insulin to preneoplastic state.
Aim: Our study aimed to explore the possible effect of high carbohydrate diet induced type II diabetes on colonic inflammation in female rats.
Experimental Protocol: Rats were divided control group (I) which is subdivided into control non inflammatory (IA) and control inflammatory (IB), diabetic group (II) subdivided into diabetic non inflammatory (IIA), and diabetic inflamma-tory (IIB). Animals were sacrificed, blood samples were collected for serum glucose, triglycerides, FFA, insulin and IGF1. Visceral fat was weighed. Detection of colonic insulin and IGF1 receptors and histopatological examination.
Results: Diabetic groups showed significant increase in all serum parameters and in IGF1 colonic receptor gene expression while decreased expression of insulin receptors. Histolpathological examination revealed colonic exacerbation of inflammation in diabetic inflammatory group in comparison to control group.
Conclusion: Insulin-IGF1 axis positively correlate with preneoplastic colon inflammation especially associated with obesity.