Serum Concentration of Free Testosterone and Insulin Resistance in Early Miscarriage in Nulliparous Women with and without Polycystic Ovarian Syndrome
/ 0
- Details
- Category: Vol. 84, December 2016
- Hits: 505
Serum Concentration of Free Testosterone and Insulin Resistance in Early Miscarriage in Nulliparous Women with and without Polycystic Ovarian Syndrome, MOHAMED A. ELNAGGAR, ASHRAF M. KANSOUH and AHMED E. EL-SHEIK
Abstract
Backgroud: Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine disorder affects 5-10% of women of reproductive age. Hyperandrogenism, chronic anovulation, and infertility are the main features of this heterogeneous condition in the absence of specific diseases of the ovaries, adrenals and pituitary.
Objective: The present study was designed to investigate serum free testosterone levels and insulin resistance associated with miscarriage in patient with and without PCOS.
Methods: The study was done at Department of Obstetrics and Gynecology at Benha and Shibeen El-Kom Teaching Hospital, from October 2015 to September 2016. It included 100 cases of early miscarried women, who were divided in two groups 50 women with PCOS (Group A); and 50 women without PCOS (Group B). All women were submitted to full history taking, thorough clinical examination and laboratory investigations; measurement of serum free testosterone, fasting plasma glucose, fasting serum insulin and estimation of insulin resistance.
Results: The results of the present study showed that, there was statistically highly significant difference between both groups as regard to serum concentration of free testoster-one; (Group (A); mean: 28.08±3.46pg/mL, Group (B); mean: 17.20±2.56pg/mL, p-value <0.001), there was statistically non-significant difference between both groups as regard to fasting plasma glucose (Group (A); mean: 87.93±2.33mg/dl, Group (B); mean: 88.53±2.15mg/dl, p-value 0.15), there was statistically highly significant difference between both groups as regard to serum fasting insulin; (Group (A); mean: 32.74± 2.46mIU/mL, Group (B); mean: 10.56±0.85mIU/mL, p-value <0.001) and there was statistically highly significant difference between both groups as regard to insulin resistance; (Group (A); mean: 0.289±0.002, Group (B); mean: 0.337±0.004, p-value <0.001).