Androgen Pattern and Erectile Function in Newly Diagnosed Type 2 Diabetes
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- Category: Vol. 84, December 2016
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Androgen Pattern and Erectile Function in Newly Diagnosed Type 2 Diabetes, AHMED I. ELSAKKA, AL-SAYED M. AL-SALAMONY and ABEER M. AHMED
Abstract
Background: In this study, we assessed the alteration of androgen pattern and Erectile Dysfunction (ED) in male patients with recently diagnosed type 2 diabetes mellitus T2DM.
Material and Methods: 176 newly diagnosed type 2 diabetic male patients underwent laboratory investigations, involving routine chemistry [glycemic indices; FBS and HbA1C] and [lipid profile; TC, TG, LDLc and HDLc]. Also, total testosterone (tT), sex hormone binding globulin, prolactin, insulin were assayed. In addition, calculated free (fT) and bioavailable (bT) testosterone were assessed. Erectile function was evaluated utilizing International Index of Erectile Function (IIEF).
Results: 21.6% and 48.3% of our diabetic patients had low total testosterone (tT) and Erectile Dysfunction (ED) respectively. There were significant associations between low total testosterone (tT), severe Erectile Dysfunction (ED) and hyperglycemia (FBS) (³200mg/dl), poorly controlled DM (HbA1c >7%) and dyslipidemia. After adjustment of co-variates, a persistent significant association between decreased total testosterone (tT) as a dependent variable and increased HbA1c as a predictor was revealed by linear regression analysis.
Conclusion: Newly diagnosed type 2 diabetic patients had a high prevalence of hypogonadism and Erectile Dysfunc-tion (ED). Severe Erectile Dysfunction (ED) and hypogonadism were significantly associated with hyperglycemia and high HbA1c in recently diagnosed type 2 diabetes mellitus T2DM.