An Overview About Pharmaceutical Preparations: Topical Gels
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- Category: Vol. 84, December 2016
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An Overview About Pharmaceutical Preparations: Topical Gels
Abstract
Aims: This study aimed to explore various aspects of gels, including their classification, properties, formulation consider-ations, manufacture, and factors influencing topical delivery. Methods: A comprehensive review of literature was con-ducted to gather information on the definition, classification, properties, formulation considerations, manufacture, and fac-tors affecting topical delivery of gels. Key concepts and find-ings from relevant studies were synthesized and analyzed. Results: Gels are semi-rigid systems classified based on colloidal phases, solvent nature, and rheological properties. Their properties, such as swelling, thixotropy, and rigidity, are influenced by various factors. Formulating pharmaceutical gels involves careful consideration of the choice of vehicle/solvent, inclusion of buffers, preservatives, antioxidants, and flavors. Manufacturing processes entail dissolving water-sol-uble excipients, adding hydrophilic polymers, and preventing air entrapment. Factors affecting topical delivery encompass physiological factors, physicochemical properties of drugs, and formulation components, influencing drug diffusion and per-meation. Conclusion: Understanding the complexities of gel formu-lation and manufacturing processes is crucial for developing effective pharmaceutical gels. Optimization of formulations and manufacturing techniques can enhance drug delivery ca-pabilities, leading to improved therapeutic outcomes and pa-tient care. Continued research and innovation in gel technology hold promise for advancing drug delivery and developing novel therapeutic solutions.