Clonidine versus Magnesium Sulphate as Adjuvant to Peribulbar Anesthesia in Cataract Surgery
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- Category: Vol. 85, September 2017
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Clonidine versus Magnesium Sulphate as Adjuvant to Peribulbar Anesthesia in Cataract Surgery, TAMER M. KHEIR
Abstract
Background and Objectives: Clonidine or magnesium sulphate may improve the quality of peribulbar block. We compared the effects of adding either clonidine or magnesium sulphate to peribulbar block in patients undergoing cataract surgery on the quality of globe akinesia. Clonidine has been shown to increase the duration of analgesia and anesthesia produced by local anesthetics.
Methods: 90 adult patients undergoing cataract surgery were randomly allocated into three groups. Peribulbar block was performed by 8ml bupivacaine 0.5%, hyaluronidase 75IU diluted in normal saline to a total volume of 10ml in control group. 1mg/kg clonidine diluted in 1ml normal saline and 50mg magnesium sulphate (10%) were added to the same mixture in clonidine and magnesium groups respectively. Onset and duration of lid and globe akinesia, adequate time to start surgery and duration of postoperative analgesia were recorded.
Results: Addition of clonidine significantly enhanced the onset of lid (1.54±0.43min) and globe akinesia (2.19±0.75min) as well as adequate time to start surgery (6.23±1.8min) compared to both control (p<0.05) and magnesium sulphate (p<0.05) groups while the comparison between control and magnesium sulphate groups was statistically insignificant (p>0.05). Time of first analgesic request was significantly prolonged in both clonidine and magnesium sulphate groups compared to the control group (p<0.05).
Conclusions: Addition of clonidine (1mg/kg) or magnesium sulphate (50mg) to peribulbar block in patients undergoing cataract surgery equally prolongs the duration of post-operative analgesia.