Role of DHEA Supplementation in Improvement of Pregnancy Rates in Poor Responders
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- Category: Vol. 85, September 2017
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Role of DHEA Supplementation in Improvement of Pregnancy Rates in Poor Responders, AYMAN A. MARZOUK, EMAD M. SALAH, DOAA A. ABD EL-FATTAH and HANAN A. MEDANY
Abstract
Background: Poor responders were classified with at least two of the three following criteria: (I) Advanced maternal age or any other risk factor for POR; (II) A previous; and (III) An abnormal Ovarian Reserve Test (ORT): As described by the Bologna criteria.
Objective: To evaluate the role of DHEA supplementation in improvement of pregnancy rates in poor respondrs.
Methods: 100 patients attending Kasr El-Ainy IVF Unit from May 2013 to December 2014 and classified as poor responders according to ESHRE consensus 2011 were included. All the patients were subjected to GnRhshort agonist. Group A patients will not receive (n=50) DHEA (control group). Group B patients (n=50) will receive DHEA in a dose of 25mg t.i.d. for 3 months prior to their second ICSI/embryo transfer cycle.
Results: Our study found that there were no statistical differences between DHEA group and control group regarding pregnancy rate.
Conclusion: Poor ovarian response is an obstacle for success of IVF. Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant to IVF treatment protocols in poor responders in a trial to improve IVF results.