Role of DHEA Supplementation in Improvement of Number of Retrieved Oocytes and Transferred Embryoes in Poor Responders
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- Category: Vol. 85, September 2017
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Role of DHEA Supplementation in Improvement of Number of Retrieved Oocytes and Transferred Embryoes in Poor Responders, AYMAN A. MARZOUK, EMAD M. SALAH, DOAA A. ABD EL-FATTAH and HANAN A. MEDANY
Abstract
Background: Poor ovarian response is an important lim-iting factor to success in in-vitro fertilization. It is encountered in approximately 10-15% of women undergoing conventional IVF. The cause of this remains unexplained in the large majority, in addition to the reduced success rate, emotional and financial burden associated with this diagnosis are well-understood.
Objective: To evaluate the role of DHEA supplementation in improvement of number of retrieved oocytes and transferred embryos in poor responders.
Methods: 100 patients attending Kasr El-Ainy IVF Unit from May 2013 to December 2014 and classified as poor responders according to ESHRE consensus 2011 were included. All the patients were subjected to GnRh short agonist. Group A patients will not receive (n=50) DHEA (control group). Group B patients (n=50) will receive DHEA in a dose of 25mg t.i.d. for 3 months prior to their second ICSI/embryo transfer cycle.
Results: Our study found that there were no statistical differences between DHEA group and control group regarding number of retrieved oocytes but may improve number and quality of transferred embryos.
Conclusion: Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant to IVF treatment protocols in poor responders. It may improve number and quality of transferred embryos.