Effect of Vaginal versus Intramuscular Progesterone in Prevention of Recurrent Preterm Labor, AHMED N. ASKALANI, AMR H. HUSSEIN and KHALED M. KHOLAIF
Abstract
Objectives: The aim of this study is to compare between vaginal and intramuscular progesterone in the prevention of recurrent preterm labor.
Study Design: Comparative clinical trial.
Methodology: This study is a comparative clinical trial, which was carried out at Kasr El-Ainy Maternity Hospital during the period between January 2014 and January 2016. One hundred (100) pregnant women who have history of previous spontaneous preterm labor (s) were selected in this study and randomly arranged into three groups [vaginal progesterone Group (A), intramuscular progesterone Group (B) and control Group (C)].
Results: Preterm labor was higher among the control group in comparison to progesterone group also the vaginal progesterone was higher compared to the intramuscular pro-gesterone group in prevention of preterm labor.
Conclusion: Prophylactic use of progesterone reduces the rate of preterm labor in women with history of recurrent spontaneous preterm labors, vaginally administrated proges-terone was nearly as equally effective as intra muscular progesterone in the prevention of PTL in women at risk with superior effect with vaginal route.