Effect of Vaginal Versus Intramuscular Progesterone on the Uterine and Fetal Blood Flow in Patients with History of Recurrent Preterm Labor
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- Category: Vol. 85, September 2017
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Effect of Vaginal Versus Intramuscular Progesterone on the Uterine and Fetal Blood Flow in Patients with History of Recurrent Preterm Labor, AMR H. HUSSEIN, REHAB L. MOHAMED and KHALED M. KHOLAIF
Abstract
Objectives: The aim of this study is to compare between effect of vaginal and intramuscular progesterone on the uterine and fetal circulations and on serum progesterone level in patients with history of recurrent spontaneous preterm labor.
Study Design: Comparative clinical trial.
Methodology: This study is a comparative clinical trial, which was carried out at Kasr El-Ainy Maternity Hospital during the period between January 2014 and January 2016. One hundred (100) pregnant women with history of previous spontaneous preterm labor (s) were selected in this study and randomly arranged into three groups [vaginal progesterone Group (A), intramuscular progesterone Group (B) and control Group (C)].
Results: Fetal MCA-PI and RI, uterine artery RI and lower birth weight, were higher among the control group in compar-ison to progesterone group and serum progesterone was higher among progesterone group compared to control group.
Conclusion: Vaginally administrated progesterone and intra muscular progesterone were associated with significant reduction in fetal MCA-PI and RI, but vaginal progesterone only had significant reduction in uterine artery RI and PI.