Aortic Stiffness and Carotid Intima-Media Thickness are Increased in Healthy Subjects with Parental History of Diabetes Mellitus
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- Category: Vol. 85, September 2017
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Aortic Stiffness and Carotid Intima-Media Thickness are Increased in Healthy Subjects with Parental History of Diabetes Mellitus, MOHAMMED ABD EL-GHANY, ZEINAB ASHOUR, AHMED EL-DAMATY and MAZEN GHALEB
Abstract
Background: Previous studies have shown that high HbA1c concentrations considered within the 'normal range' may detect individuals with increased propensity for developing type 2 diabetes mellitus in the near future. Available information has also suggested that in the general population, high HbA1c concentrations may detect individuals at higher risk for cardiovascular mortality. However, little is known whether a non-diabetic subject with a family history of diabetes is at high risk for vascular damage or not. The aim of the present work was to evaluate the arterial status of healthy offspring of diabetic patients.
Methods: Fifty-six healthy subjects with parental history of diabetes were compared with fifty-six, age and sex-matched, healthy subjects without parental history of diabetes. Age, sex, body mass index, smoking habits, blood pressure, HbA1c, lipid profile were measured. Carotid intima-media thickness was measured by high-resolution B-mode ultrasound imaging, and aortic stiffness index was measured by M-mode echocar-diography.
Results: HbA1c level, carotid IMT and aortic stiffness index were significantly higher in subjects with parental history of diabetes than in subjects without parental history of diabetes (5.6±0.38 vs. 5.42±0.33, p=0.009; 0.66±0.09 vs. 0.56±0.09, p<0.001; 5.12±2.36 vs. 3.52±1.51, p<0.001, re-spectively). In all healthy subjects, HbA1c level was positively correlated with Aortic stiffness index (r=0.235, p=0.013) and carotid IMT (r=0.289, p=0.002). Also we found a positive correlation between CCA IMT and Aortic stiffness index (r= 0.685, p<0.001).
Conclusions: This study demonstrated that the CCA IMT and aortic stiffness index are significantly higher in subjects with parental history of diabetes compared with subjects without parental history of diabetes. Therefore, these findings suggest that glycemic control might have a pathophysiological relevance in the development of vascular disease, even in individuals without diabetes.