Expression of Ki-67 in Papillary Thyroid Carcinoma
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- Category: Vol. 85, December 2017
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Expression of Ki-67 in Papillary Thyroid Carcinoma, HANAN H. MOHAMMED, AMIRA M. BASSAM and ZEINAB A. EL-SHREEF
Abstract
Background: Thyroid cancer is the commonest endocrine malignancy and papillary thyroid carcinoma (PTC) is the most prevalent type. Generally, it follows an indolent course, but it can be aggressive. Various studies have been conducted to detect factors determining the prognosis of cases of papillary thyroid carcinoma. One of the known factors in tumors generally is proliferative activity of the tumor cells and Кi-67 is a useful tool for evaluating this activity.
Aim of Work: Immunohistochemical evaluation of Кi-67 expression in papillary thyroid carcinoma and correlation between its expression and clinicopathological features of this tumor.
Material and Methods: This study was conducted on 50 cases of PTC. Immunohistochemical reactions were carried out by using Кi-67 (SIB-1) monoclonal antibody for proliferative activity. Statistical analysis was done on results reached.
Results: Кi-67 labeling index was found to be low in this study, 30/50 cases (60%) showed labeling index (LI) less than or equals 1%, 11 cases (22%) showed U >1-3% and 9 cases showed expression >3% (18%). Non-significant relation was found between Кi-67 LI and the clinicopathological characteristics of РТС included in the study. However, all cases with high index showed lymph node metastasis, a known poor prognostic factor.
Conclusion: Кi-67 could be potentially useful in detecting cases of РТС with poor prognosis, however further many studies are needed to establish this conclusion.