The Association between Obesity, Obstructive Sleep Apnea and Serum Lipid Profile
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- Category: Vol. 85, December 2017
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The Association between Obesity, Obstructive Sleep Apnea and Serum Lipid Profile, ABDELHAY I. ABDEL-HAY, AYMAN A. MOHAMED, MAHMOUD M. MOHAMED and ZAKARIA M.Z.A. ABOTAHA
Abstract
Background: Obstructive Sleep Apnea (OSA) is a common sleep disorder that is characterized by intermittent, complete, and partial airway collapse resulting in frequent episodes of apnea and hypopnea. In human studies, most of which were clinic based, Dyslipidemia (DL) was found more frequently in patients with OSA than in subjects without OSA. However, it is still controversial whether OSA correlates independently with the serum lipid profile or what components of the serum lipid profile are associated with Obstructive Sleep Apnea (OSA),
Objective: To assess the association between obstructive sleep apnea and serum lipid profile in obese patients.
Subjects and Methods: This study was conducted at Sleep Disorders Unit in Chest Department, Bab El-Sha'aria Hospital, Al-Azhar University in the period between January 2017 to August 2017. The study included two groups:
Group (1): Thirty obese patients with a mean age of (53, 9±5.9) attending Al-Azhar University Hospitals during the period of the study.
Group (2): Ten apparently healthy non-obese subjects were incorporated as control group. The controls were well matched to the patients for age and gender.
All patients and healthy subjects after providing written informed consent were subjected to full medical history, clinical examination including ENT examination to exclude local causes of Obstructive Sleep Apnea (OSA), measurement of neck circumference, calculation of BMI, pulmonary function tests, arterial blood gases analysis, assessment of serum lipid profile and Polysomnography (PSG).
Results: 25 patients out of 30 obese patients (83%) had obstructive sleep apnea. Patients with obstructive sleep apnea had significantly higher BMI than those without obstructive sleep apnea (43.1kg/m2 ±9.2 and 34.8kg/m2 ±4. 1 respectively with p-value 0.03).
Obese patients with obstructive sleep apnea had non-significant higher levels of TG, TC, and LDL (168.8mg/dl ±17.6, 205.7mg/dl ±10.6 and 119.8mg/dl ±7.7 respectively) and non-significant lower level of HDL (50.6mg/dl ±7.4) compared to those without obstructive sleep apnea. Obese