Study of the Effect of Topical Antiglucoma Medications with Different Preservatives as Monotherapy on Dry Eye
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- Category: Vol. 85, December 2017
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Study of the Effect of Topical Antiglucoma Medications with Different Preservatives as Monotherapy on Dry Eye, OSAMA A. SALIM, AMR I. EL-AWAMRY, YASSER A. EL-ZANKLONY and REEM A. ABOU EL-MAGD
Abstract
Aim of the Study: Study of the effect of topical antiglau-coma medications with different preservatives as Purite preservative and Benzalkonium chloride on the ocular surface and dry eye.
Methodology: This is cross section case-control study in which we tested the effect of topical antiglaucoma medications with different preservatives. Our study included 20 controls (Group A) and 40 glaucoma patients (Group B) divided into 20 patients using Alpha-agonist eyedrops containing Purite as preservative and 20 patients using B-blocker eyedrops containing Benzalkonium Chloride (BAK) as preservative. The patients were recruited from Outpatient Clinic of Ain Shams University Hospital and the controls from the patients coming to the outpatient clinic seeking correction of an error of refraction during the period from May 2016 to December 2016.
Results: Our study showed that ocular surface damage in glaucoma patients is associated with preserved topical medi-cations. There were statistically significant differences between the glaucoma-treated patients (used Alpha agonist eyedrops with Purite preservative and B blocker eyedrops with BAK as preservative) and control group in the clinical tests used to diagnose Ocular Surface Disease (OSD). In this study, Tear Break Up Time (TBUT) was significantly reduced in glaucoma patients with topical medications as compared to that in controls. Also the Schirmer test values were significantly different between glaucoma-treated patients and untreated controls.
Conclusion: B blocker eyedrops induce more damage on the ocular surface compared to Alpha agonist eyedrops sug-gesting that Purite preservatives have less dryness effect than BAK-chloride preservatives.