Tumor Necrosis Factor Receptor in Egyptian Patients with Bipolar Disorder during Euthymia: A Case Controlled Study
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- Category: Vol. 85, December 2017
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Tumor Necrosis Factor Receptor in Egyptian Patients with Bipolar Disorder during Euthymia: A Case Controlled Study, AREF A. KHOWEILED, OSAMA R. IBRAHIM, NAGWAN M. MADBOULY, WALAA A. RABIE and NOHA A. MAHFOUZ
Abstract
Background: The role of inflammation has received increasing attention as a potential pathophysiological mecha-nism in Bipolar Disorder (BD).
Objective: To compare the level of soluble Tumor Necrosis Factor Receptor 1 (sTNFR1) in euthymic state of BD to healthy controls.
Methods: Serum levels of sTNFR1 were measured with enzyme linked immunosorbent assay techniques in 44 patients with BD-I in full remission and 88 healthy controls recruited from Kasr Al-Ainy Hospital, Cairo University. The severity of the manic symptoms was assessed using Young Mania Rating Scale (YMRS). Patients with BD-I in full remission were subjected to Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS).
Results: The level of sTNFR1 was higher in the healthy control goup compared to patients with BD-I in full remission.
Conclusion: sTNFR1 can’t be considered as trait marker in patients with BD-I during full remision.