Diagnostic Impact of PET/CT over CECT in Post Therapeutic Evaluation of Colorectal Cancer
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- Category: Vol. 85, June 2017
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Diagnostic Impact of PET/CT over CECT in Post Therapeutic Evaluation of Colorectal Cancer, MOHAMED T. ALI, MOHAMED D. HOMOS and DOAA M. NABIL
Abstract
Objective: To evaluate the effectiveness of FDG PET/CT compared with routinely used MSCT in post therapeutic assessment of colorectal cancer.
Patients and Methods: A total number of 70 patients (30 women, 40 men; mean age, 48.7y), referred for re-evaluation of colorectal carcinoma after treatment. Retrospective assess-ment of cases was done by two experienced readers: First, MSCT, second PET/CT. The number, localization, and diag-nostic certainty of lesions were evaluated. In 30 patients, histopathology, imaging, and clinical follow-up were consid-ered as the reference standards. In 40 patients, both clinical follow-up and imaging were considered as the reference standards.
Results: The overall comparison between CECT and PET/CT showed significant superiority of PET/CT (sensitivity 90%, specificity 84%, PPV 89% and NPP 85%) as compared to CECT (sensitivity 42%, specificity 29%, PPV 55% and NPP 20%) respectively.
Conclusion: 18F-FDGPET/CT has shown its more effec-tiveness over CECT only in staging and follow-up of patients with colorectal cancer as PET/CT was more sensitive in identifying sites of recurrent or metastatic disease as well as monitoring treatment response so patients with inconclusive CECT findings now are subsequently evaluated by 18FFDG PET/CT.