Diagnostic Values of Troponin-I in Relation to miRNA-208 in ACS Patients
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- Category: Vol. 85, June 2017
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Diagnostic Values of Troponin-I in Relation to miRNA-208 in ACS Patients, MARWA M. MOSTAFA, MANAL A. MOHAMED, KHALED S. AHMED and WALEED F. ABD EL-AZIM
Abstract
Background: ACS patients presented to ED require rapid differential diagnosis. Although troponin is the gold marker for ACS. microRNAs circulate in human plasma and affected by varying cardiac pathologies. miRNA-208 was found to be elevated with ACS specially AMI.
Aim of Work: The aim of this study was to investigate cTnI and copeptin levels, correlated to miRNA-208 levels in ACS patients to evaluate rapid, accurate and final diagnosis in ED.
Subjects and Methods: Sixty two consecutive patients with ACS presenting to the Emergency Department of the National Heart Institute, Giza (Egypt) between March and June 2015, were recruited for the study, grouped into two groups according to the final diagnosis as AMI (including thirty two patients) and UA (including thirty patients) groups. Their cardiac markers and miRNA-208 levels were assayed and compared to a control healthy group on admission.
Results: Results revealed significant difference between cardiac levels on admission compared to that obtained for miRNA-208. Only copeptin and miRNA-208 levels were diagnosing on admission compared to that of cTnI.
Conclusion: Early measurement of troponin I and copeptin may revolutionize the diagnostic accuracy and therapeutic decision-making in patients with symptoms suggestive of ACS; differentiate between UA or AMI patients on admission. miRNA-208 has found to be increased up to 38.6 folds without differential cut off and can be used as a novel marker for early diagnosis of ACS although RT-PCR still time consuming, requires time improved techniques.