VEGF and HsCRP in Predicting Severity of Pre-Eclampsia among Egyptian Females
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- Category: Vol. 85, June 2017
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VEGF and HsCRP in Predicting Severity of Pre-Eclampsia among Egyptian Females, MAHMOUD H. ZAATAR, SOLAF A. KAMEL, AHMED S. NASR, MOHAMED A. EL-NOURI, and OSSAMA M. AZMY
Abstract
Background: Pre-Eclampsia (PE) is one of the most important causes of maternal and fetal morbidity and mortality. The aim was to study the association between VEGF C-460T SNP (rs 833061) and serum concentrations of HsCRP with the severity of pre-eclampsia.
Methods: A case control study of 90 pregnant women was enrolled (30 mild pre-eclampsia, 30 severe pre-eclampsia and 30 normal pregnant as control). VEGF C-460T SNP (rs 833061) was determined by real-time PCR method. Serum concentration of CRP was evaluated by Elisa.
Result: HsCRP was significantly higher in severe pre-eclampsia in comparison to mild pre-eclampsia (p<0.001) and in comparison to the control (p<0.001). There were no signif-icant differences in the allele and genotype frequencies of VEGF C-460T SNP among the severe pre-eclampsia, mild and control groups (p>0.055), however, the statistical signif-icant difference was observed between severe and mild pre-eclampsia groups (p=0.035). TT carriers had an increased risk of severe pre-eclampsia as compared to the mild pre-eclampsia group (p=0.035), however, there were no significant difference in the risk of pre-eclampsia between TT carriers of mild and control groups (p=0.717).
Conclusion: Carriers of VEGF C-460T allele may have increased risk of severe pre-eclampsia. HsCRP levels increased in severe pre-eclampsia and can be used as a marker of severe pre-eclampsia.