VEGF and CA-125 in Predicting Severity of Preclampsia among Egyptian Females
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- Category: Vol. 85, June 2017
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VEGF and CA-125 in Predicting Severity of Preclampsia among Egyptian Females, MAHMOUD H. ZAATAR, SOLAF A. KAMEL, AHMED S. NASR, MOHAMED A. EL-NOURI and OSSAMA M. AZMY
Abstract
Background: Pre-eclampsia (PE) is one of the most im-portant causes of maternal and fetal morbidity and mortality. The aim was to study the association between VEGF C-460T SNP (rs 833061) and (CA-125) with severity of pre-eclampsia.
Methods: A case control study of 90 pregnant women was enrolled (30 mild pre-eclampsia, 30 severe pre-eclampsia and 30 normal pregnant as control). VEGF C-460T SNP (rs 833061) was determined by real-time PCR method. Serum concentration of CA-125 levels was evaluated by Elisa.
Result: CA-125 was significantly higher in severe preec-lampsia in comparison the control (p<0.017). No significant difference was observed between severe preeclampsia and mild preeclampsia (p=0.128) or between mild preeclampsia and control (p=0.389). There were no significant differences in the allele and genotype frequencies of VEGF C-460T SNP among the severe preeclampsia, mild and control groups (p>0.055), however, the statistical significant difference was observed between severe and mild preeclampsia groups (p= 0.035). TT carriers had an increased risk of severe preeclampsia as compared to the mild preeclampsia group (p=0.035), however, there were no significant difference in the risk of preeclampsia between TT carriers of mild and control groups (p=0.717).
Conclusion: Carriers of VEGF C-460T allele may have increased risk of severe preeclampsia. CA-125 levels increased in severe pre-eclampsia and can be used as markers of severe preeclampsia.