Serum Neoptrin Level as a Marker for Activity in Chronic Hepatitis B Virus Infection
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- Category: Vol. 84, September 2016
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Serum Neoptrin Level as a Marker for Activity in Chronic Hepatitis B Virus Infection, NAGWA SHAWKI, MAHER BORAI, EMAN MONEER, TALAAT FATHY and AMAL A. JOUDA
Abstract
Background: Neoptrin is secreted by activated macroph-ages. Its serum level reaches peak with appearance of clinical manifestations of the viral infection and declines by conva-lescence. Neoptrin level can be a marker of HBV activity and replication and hence, need for treatment.
Patients and Methods: Ninty patients were included in this study. Group I (30 healthy volunteers). Group II (30 patients with HBV DNA <2000IU/ml and normal enzymes, inactive carrier) Group III (30 patients with HBV DNA >2000IU/ml and elevated liver enzymes, active hepatitis).
Results: Neoptrin level was higher in Group II than Group I (2.97±1.02 vs 0.44±0.33ng/L p<0.001) and more higher in Group III (14.1±9.07ng/L). Neoptrin is significantly correlated to ALT, AST and HBV DNA in serum (r=0.94 in Group II and 0.96 in Group III p<0.001).
Conclusion: Neoptrin is a good marker for activity in chronic HBV infection.