The Usefulness of Glycated Albumin for Evaluation of Glycemic Control in Egyptian Type 2 Diabetic Patients
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- Category: Vol. 85, March 2017
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The Usefulness of Glycated Albumin for Evaluation of Glycemic Control in Egyptian Type 2 Diabetic Patients, GHADA H. SAYED and MOHSEN KHALID
Abstract
Background: Diabetes is one of the most common endo-crine disorders characterized by hyperglycemia. Strict glycemic control in patients with diabetes decrease the incidence of diabetic complications. Although HbA1c is the most useful measure of glycemic control in the vast majority of patients with diabetes, there are some situations that might require an alternative way to measure glycemic control. Glycated albumin is known to reflect short term glycemic levels, and could be a useful therapeutics monitor in DM because the half life of albumin (17 days) is shorter than that of erythrocytes.
Aim of the Work: This study was designed to evaluate the usefulness of Glycated Albumin in glycemic control in Egyp-tian type 2 diabetic patients attending in the National Institute of Diabetes and Endocrinology (NIDE).
Subjects and Methods: This study was conducted on a total number of 124 subjects which were subdivided as follows: Group I: Included 20 subjects with recent type 2 diabetes. The duration of diabetes ranged from 6 months to 1 year subjects. Group II: Included 79 subjects with type 2 diabetes. The duration of diabetes ranged from 5 to 10 years. Group III: 25 normal healthy subjects (served as controls), not suffering from any disease interfering with our study. They were not receiving any medications. In addition to the routine investigation serum glycated albumin levels were measured using Enzyme Linked Immunosorbant Assay (ELISA) tech-nique.
Results: We found that: By comparing mean values of GA, GHb (HbA1c) and GA/GHb ratio between the three studied groups we found that there were a statistical significant difference between the three studied groups as regard the three parameters. GA were significantly higher in group 2 than group 1, and in group 1 than in group 3. It was found that there were positive correlations between GA and GHb, GA/GHb ratio, ACR, ALB, FBS and duration of diabetes while GA was not correlated with other investigated parame-ters. Also it was noticed that there was positive correlation between GHb and FBS. Comparison between first visit and second visit after adjustment the treatment by the physician as regard GA and GHb showed highly statistical significant difference as regard GA while there were statistical significant differences as regard GHb.
Conclusion: It can be concluded that GA superior to GHb in short duration assessment but we can not deduce that there is usefulness to GA over GHb to be an indicator to uncontrolled diabetes.