Association of Insulin Growth Factor 2 Binding Protein 2 Gene rs4402960 Polymorphism with Type 2 Diabetes Mellitus in A Sample from Egyptian Patients

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Category: Vol. 87, March 2019

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Association of Insulin Growth Factor 2 Binding Protein 2 Gene rs4402960 Polymorphism with Type 2 Diabetes Mellitus in A Sample from Egyptian Patients, YASSER M. ISMAEL, SAHAR M. FAYED, DALIA M. ABD EL-HASSIB and BASMA G.A. BEHAIRY

Abstract
Background: Genetic variation at the insulin growth factor 2 binding protein 2 (IGF2BP2) gene has been associated with Type 2 Diabetes (T2DM) by genome-wide association studies.
Aim of Study: To assess the genetic association of insulin growth factor 2 binding protein 2 (IGF2BP2) rs4402960 polymorphism with the development of type 2 diabetes mellitus in a sample from Egyptian patients.
Patients and Methods: 50 subjects; 30 T2DM patients and 20 healthy controls. They were subjected to: History, clinical examination, measuring glycosylated hemoglobin, lipid profile and genotyping of IGF2BP2 (rs4402960) using Taqman-based allelic discrimination technique by Real-Time PCR.
Results: There was significant statistical difference re-garding allele frequency of IGF2BP2 (rs4402960) as it exhib-ited an increased T allele frequency in the diabetic group while G allele was decreased compared to controls. The allelic association analysis confirmed a significant association with T2DM [OR=7.43, p=<0.001 ]. The frequency of (G/T + T/T) genotypes vs. G/G was significantly higher in T2DM patients than in controls [p=0.022, OR=0.26].
Conclusion: IGF2BP2 rs4402960 was significantly asso-ciated with increased risk of T2DM and can be used to predict the disease in Egyptian patients, and it is recommended to do this study on a large scale to confirm this association.

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