Evaluation of the Clinical Effects of Ombitasvir/Paritaprevir/Ritonavir Regimen in the Treatment of Chronic HCV Patients in CKD Versus ESRD Patients in Assiut University Hospital

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Category: Vol. 87, March 2019

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Evaluation of the Clinical Effects of Ombitasvir/Paritaprevir/Ritonavir Regimen in the Treatment of Chronic HCV Patients in CKD Versus ESRD Patients in Assiut University Hospital, SHALA Kh. EL-SHERIF, ESSAM M. ABD EL-AZIZ and MONA ABD EL-LATIF ALI

Abstract

Background: Assesing curability of Ombitasvir/Parit-aprevir/Ritonavir regimen in chronic HCV infected patients in those with ESRD and CKD.

Aim of Work: To asses, curability of Ombitasvir/Paritap-revir/Ritonavir in chronic HCV infected patients in those with ESRD vs CKD, and assess duration of sustained viral therapy in Assiut Hospital University.

Patients and Methods: It is a prospective study which included 40 patients at Hemodialysis unit and Internal Medicine department in Assiut University Hospitals though one year. Then Patient will be divided into 2 group: Group I: 20 ESRD Patients on regular heamodialysis >6 months with chronic HCV infection. Group II: 20 CKD Patients with chronic HCV infection did not start dialysis.

Results: (SVR) was assessed at 12 and 24 weeks post-therapy. All patients in each group achieved SVR at 12 weeks but at 24 week. 85% of patients with ESRD achieved SVR while all those with CKD achieved SVR.

Conclusion: We found that the curability of Ombitasvir /Paritaprevir/Ritonavir plus Ribavirin has SVR12 about 100% and SVR24 100% in CKD patients, 85% in ESRD patients. With less incidence of anemia with that regimen as only 10% patients need blood transfusion. With high tolerability and less side effects with no occurrence of discontinuation of treatment.

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