Progressive and Prognosis Role of Lipogenic Pathway in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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Category: Vol. 87, March 2019

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Progressive and Prognosis Role of Lipogenic Pathway in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis, REHAB M. SAMAKA, MOHAMMAD I. SHABAN, MERVAT M. SULTAN, SHEREEN F. EL-GODAY and DINA M. SWEED

Abstract
Background and Aims: Despite the advance in treatment modalities, Hepatocellular Carcinoma (HCC) remains a com-mon cause of cancer morbidity and mortality worldwide. Lipogenic pathway is expected to become a potential thera-peutic target for prevention and treatment of HCC.
Aim of Study: Studying the role of lipogenic pathway in hepatocellular carcinoma.
Material and Methods: We searched the PubMed and Google scholar databases for relevant studies that evaluated the expression of lipogenic pathway markers; Sterol Regulatory Element-binding Protein1 (SREBP1), Fatty Acid Synthase (FASN) and Stearoyl-CoA Desaturase1 (SCD1) in human HCC tissues.
Results: This review included 12 studies that enrolled 1031 patients with HCC or chronic hepatitis and normal subjects. SREBP1, FASN and SCD1 were overexpressed in HCC. SREBP1 expression was positively correlated with FASN and SCD expressions (r=0.74, p<0.001 and r=0.82, p <0.001, respectively). Overexpression of SREBP1 and SCD1 was associated with poor clinico-pathological data and poor Overall Survival (OS) (HR=23.09; 95% CI=1.21-438.67; p =0.04) and (HR=6.82; 95% CI=3.53-13.16; p<0.001), respec-tively.
Conclusion: We concluded that lipogenic pathway acti-vation plays an important role in HCC development and prognosis. This review was registered with PROSPERO (CRD 42018087933).

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