A Comparative Study of Immunoglobulin (E) Levels in the Nasal Mucosa and Blood in Chronic Rhinosinusitis Patients With and Without Nasal Polyps

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Category: Vol. 87, March 2019

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A Comparative Study of Immunoglobulin (E) Levels in the Nasal Mucosa and Blood in Chronic Rhinosinusitis Patients With and Without Nasal Polyps, MOHAMED S.M. KASSEM, EMAD M.K. SHEHATA, HASSAN M. HEGAZY and YASSER I. AGLAN

Abstract
Background: Rhinosinusitis is a significant health problem, which results in a large financial burden on the society. Chronic rhinosinusitis is a multi-factorial disease. These factors are mucociliairy impairment, (bacterial) infection, allergy, asthma, genetic factors and environmental factors. Critical analysis of the papers linking atopy as a risk factor to rhinosinusitis (chronic or acute). Immunoglobulin E (IgE) levels increase when patient exposed to common antigens (e.g., house dust, animal dander and pollen) with increased production of allergen-specific IgE.
Aim of Study: The aim of this work is to compare the level of IgE in the nasal mucosa and blood in chronic rhinos-inusitis patients with and without nasal polyps.
Patients and Methods: 60 patients, presented with Chronic rhinosinusitis with and without nasal polyps were enrolled in the study. Patients were divided into two groups: (Group I) Chronic rhinosinusitis patients with nasal polyps and (group II) Chronic rhinosinusitis patients without nasal polyps. Levels of total and local IgE were measured in two groups.
Results: Group I show that local IgE was high than normal but total IgE was within normal range. Group II shows that local and total IgE were within normal range.
Conclusions: This study suggests a higher prevalence of allergy in Chronic Rhinosinusitis patients with Nasal Polyps (CRSwNP) than Chronic Rhinosinusitis patients without Nasal Polyps (CRSsNP).

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