Effect of Glycemic Control on Adipokines in Diabetic Patients with Pulmonary Hypertension

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Category: Vol. 87, March 2019

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Effect of Glycemic Control on Adipokines in Diabetic Patients with Pulmonary Hypertension, MANAR M. EL-ZAKI, NADER KANDIL, SAMIA HUSSEIN, MAI M. HASAN and ABEER A. SAEED

Abstract

Background: Recent studies suggested a role of diabetes in regulating the outcome of pulmonary hypertension. Several cytokines are dysregulated in pulmonary hypertension, and were considered accurate predictors of the prognosis.

Aim of Study: To evaluate the effects of glycemic control on hemodynamics, metabolic and adipokines (leptin, apelin and adiponectin) levels in patients with pulmonary hyperten-sion and diabetes.

Subjects and Methods: Thirty-five pulmonary hypertension patients with diabetes assigned into two groups according to glycosylated hemoglobin (HbA1c) level; tightly controlled group (Group I) (n=20) and conventionally controlled group (Group II) (n=15). Demographic characteristics, hemodynamic assessment, metabolic and serum adipokines levels were assesed.

Results: Both groups showed insignificant difference in age, BMI and left ventricular ejection fraction; while mean pulmonary arterial pressure, HbA1c, fasting blood glucose, insulin, HOMA-IR, Cholesterol, triglycerides, Interleukin-6, leptin and apelin were significantly decreased in group I. IL-6, leptin and apelin have significant positive correlation with glucose, insulin, HOMA-IR, Cholesterol, TG and MPAP in both groups.

Conclusion: Good glycemic control has an impact on hemodynamics, metabolic, inflammatory and adipokine pattern in diabetic patients with pulmonary hypertension, which may affect the progression of the disease.

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